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1

Transposons for cancer gene discovery:Sleeping Beautyand beyond

Lara S Collier, David A Largaespada

Journal:

Year:

2007

Language:

english

File:

PDF, 663 KB

english, 2007

2

Cancer Gene Discovery Using the Sleeping Beauty Transposon

Starr, Timothy K., Largaespada, David A.

Journal:

Year:

2005

Language:

english

File:

PDF, 533 KB

english, 2005

3

Transposons As Tools for Functional Genomics in Vertebrate Models

Kawakami, Koichi, Largaespada, David A., Ivics, Zoltán

Journal:

Trends in Genetics

Year:

2017

Language:

english

File:

PDF, 3.78 MB

english, 2017

4

CRISPR/Cas9 library screening for drug target discovery

Kurata, Morito, Yamamoto, Kouhei, Moriarity, Branden S., Kitagawa, Masanobu, Largaespada, David A.

Journal:

Journal of Human Genetics

Year:

2017

Language:

english

File:

PDF, 506 KB

english, 2017

5

Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor

Park, Linda S., Martin, Unja, Garka, Kirsten, Gliniak, Brian, Di Santo, James P., Muller, Werner, Largaespada, David A., Copeland, Neal G., Jenkins, Nancy A., Farr, Andrew G., Ziegler, Steven F., Morr

Journal:

Journal of Experimental Medicine

Year:

2000

Language:

english

File:

PDF, 254 KB

english, 2000

6

Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype

Stephen M. Wiesner, Jennifer L. Geurts, Miechaleen D. Diers, Rachel J. Bergerson, Diane E. Hasz, Kelly J. Morgan, David A. Largaespada

Journal:

American Journal of Hematology

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

7

Transposition and gene disruption in the male germline of the mouse

Adam J. Dupuy, Sabine Fritz, David A. Largaespada

Journal:

Year:

2001

Language:

english

File:

PDF, 292 KB

english, 2001

8

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver

Kirk J. Wangensteen, Andrew Wilber, Vincent W. Keng, Zhiying He, Ilze Matise, Laura Wangensteen, Corey M. Carson, Yixin Chen, Clifford J. Steer, R. Scott McIvor, David A. Largaespada, Xin Wang, Stephe

Journal:

Year:

2008

Language:

english

File:

PDF, 983 KB

english, 2008

9

Modeling hepatitis B virus X–induced hepatocellular carcinoma in mice with the sleeping beauty transposon system

Vincent W. Keng, Barbara R. Tschida, Jason B. Bell, David A. Largaespada

Journal:

Year:

2011

Language:

english

File:

PDF, 835 KB

english, 2011

10

The GAP-related domain of neurofibromin attenuates proliferation and downregulates N- and K-Ras activation in Nf1-negative AML cells

Kelly J. Morgan, Matthew A. Rowley, Stephen M. Wiesner, Diane E. Hasz, Brian Van Ness, David A. Largaespada

Journal:

Leukemia Research

Year:

2007

Language:

english

File:

PDF, 469 KB

english, 2007

11

Hyperdiploid karyotype in a childhood MDS patient

Hasan Acar, Ümran Çalişkan, Murat Kaynak, M. Selman Yildirim, David A. Largaespada

Journal:

International Journal of Laboratory Hematology (Blackwell)

Year:

2001

Language:

english

File:

PDF, 52 KB

english, 2001

12

Conditional gene expression in the mouse using aSleeping Beautygene-trap transposon

Aron M Geurts, Andrew Wilber, Corey M Carlson, Paul D Lobitz, Karl J Clark, Perry B Hackett, R Scott McIvor, David A Largaespada

Journal:

BMC Biotechnology

Year:

2006

Language:

english

File:

PDF, 1.30 MB

english, 2006

13

Micronucleus incidence and their chromosomal origin related to therapy in acute lymphoblastic leukemia (ALL) patients: Detection by micronucleus and FISH techniques

Hasan Acar, Ümran Çalişkan, Sennur Demirel, David A. Largaespada

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Year:

2001

Language:

english

File:

PDF, 28 KB

english, 2001

14

Efficient mammalian germline transgenesis by cis-enhancedSleeping Beautytransposition

Daniel F. Carlson, Aron M. Geurts, John R. Garbe, Chang-Won Park, Artur Rangel-Filho, Scott M. O’Grady, Howard J. Jacob, Clifford J. Steer, David A. Largaespada, Scott C. Fahrenkrug

Journal:

Transgenic Research

Year:

2011

Language:

english

File:

PDF, 776 KB

english, 2011

15

DNA methylation of Sleeping Beauty with transposition into the mouse genome

Chang Won Park, Betsy T. Kren, David A. Largaespada, Clifford J. Steer

Journal:

Year:

2005

Language:

english

File:

PDF, 549 KB

english, 2005

16

Markers of prostate region-specific epithelial identity define anatomical locations in the mouse prostate that are molecularly similar to human prostate cancers

Joshua L. Thielen, Katherine G. Volzing, Lara S. Collier, Laura E. Green, David A. Largaespada, Paul C. Marker

Journal:

Differentiation

Year:

2007

Language:

english

File:

PDF, 937 KB

english, 2007

17

10.1038/15531

Copeland, Neal G., Li, Jiayin, Shen, Haifa, Himmel, Karen L., Dupuy, Adam J., Largaespada, David A., Nakamura, Takuro, Shaughnessy, John D., Jenkins, Nancy A.

Journal:

Nature Genetics

Year:

1999

Language:

english

File:

PDF, 135 KB

english, 1999

18

A method for lifelong genetic manipulation of regenerating hepatocytes in mouse

Wangensteen, Kirk J, Wilber, Andrew, Keng, Vincent W, Chen, Yixin, Matise, Ilze, Wangensteen, Laura, Steer, Clifford J, McIvor, R Scott, Largaespada, David A, Wang, Xin

Journal:

Year:

2008

Language:

english

File:

PDF, 235 KB

english, 2008

19

Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

Collier, Lara S., Carlson, Corey M., Ravimohan, Shruthi, Dupuy, Adam J., Largaespada, David A.

Journal:

Year:

2005

Language:

english

File:

PDF, 297 KB

english, 2005

20

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system

Dupuy, Adam J., Akagi, Keiko, Largaespada, David A., Copeland, Neal G., Jenkins, Nancy A.

Journal:

Year:

2005

Language:

english

File:

PDF, 554 KB

english, 2005

21

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

Nakamura, Takuro, Largaespada, David A., Shaughnessy, John D., Jenkins, Nancy A., Copeland, Neal G.

Journal:

Nature Genetics

Year:

1996

File:

PDF, 526 KB

1996

22

Nf1 deficiency causes Ras-Dediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

Largaespada, David A., Brannan, Camilynn I., Jenkins, Nancy A., Copeland, Neal G.

Journal:

Nature Genetics

Year:

1996

File:

PDF, 873 KB

1996

23

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

Nakamura, Takuro, Largaespada, David A., Lee, Maxwell P., Johnson, Laura A., Ohyashiki, Kazuma, Toyama, Keisuke, Chen, Sai Juan, Willman, Cheryl L., Chen, I-Ming, Feinberg, Andrew P

Journal:

Nature Genetics

Year:

1996

File:

PDF, 548 KB

1996

24

Insertional mutagenesis in mice: new perspectives and tools

Carlson, Corey M., Largaespada, David A.

Journal:

Nature Reviews Genetics

Year:

2005

Language:

english

File:

PDF, 655 KB

english, 2005

25

Mrvil, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1

Jr, John D Shaughnessy, Largaespada, David A, Tian, Erming, Fletcher, Colin F, Cho, Brian C, Vyas, Paresh, Jenkins, Nancy A, Copeland, Neal G

Journal:

Year:

1999

Language:

english

File:

PDF, 807 KB

english, 1999

26

Evi27 encodes a novel membrane protein with homology to the IL17 receptor

Tian, Erming, Sawyer, Jeffrey R, Largaespada, David A, Jenkins, Nancy A, Copeland, Neal G, Shaughnessy, John D

Journal:

Year:

2000

Language:

english

File:

PDF, 556 KB

english, 2000

27

TAPDANCE: An automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data

Aaron L Sarver, Jesse Erdman, Tim Starr, David A Largaespada, Kevin A T Silverstein

Journal:

BMC Bioinformatics

Year:

2012

Language:

english

File:

PDF, 867 KB

english, 2012

28

Modeling myeloid leukemia tumor suppressor gene inactivation in the mouse

Kevin M Shannon, Michelle M Le Beau, David A Largaespada, Nigel Killeen

Journal:

Seminars in Cancer Biology

Year:

2001

Language:

english

File:

PDF, 320 KB

english, 2001

29

The ABL-MYC retrovirus generates antigen-specific plasmacytomas by in vitro infection of activated B lymphocytes from spleen and other murine lymphoid organs

David A. Largaespada, Mark W. Jackson, Nancy E. Thompson, Donal A. Kaehler, Linda G. Byrd, J.Frederic Mushinski

Journal:

Journal of Immunological Methods

Year:

1996

Language:

english

File:

PDF, 1.05 MB

english, 1996

30

Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia

Bin Yin, Scott C. Kogan, Ross A. Dickins, Scott W. Lowe, David A. Largaespada

Journal:

Experimental Hematology

Year:

2006

Language:

english

File:

PDF, 348 KB

english, 2006

31

Vav promoter-tTA conditional transgene expression system for hematopoietic cells drives high level expression in developing B and T cells

Won-Il Kim, Stephen M. Wiesner, David A. Largaespada

Journal:

Experimental Hematology

Year:

2007

Language:

english

File:

PDF, 609 KB

english, 2007

32

Detection of Integrated Murine Leukemia Viruses in a Mouse Model of Acute Myeloid Leukemia by Fluorescence In Situ Hybridization Combined with Tyramide Signal Amplification

Hasan Acar, Neal G Copeland, Debra J Gilbert, Nancy A Jenkins, David A Largaespada

Journal:

Cancer Genetics and Cytogenetics

Year:

2000

Language:

english

File:

PDF, 334 KB

english, 2000

33

Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes

Takashi Fujino, Yukari Yamazaki, David A Largaespada, Nancy A Jenkins, Neal G Copeland, Katsuiku Hirokawa, Takuro Nakamura

Journal:

Experimental Hematology

Year:

2001

Language:

english

File:

PDF, 899 KB

english, 2001

34

A bad rap: Rap1 signaling and oncogenesis

David A Largaespada

Journal:

Year:

2003

Language:

english

File:

PDF, 62 KB

english, 2003

35

Mammalian Homologues of the Drosophila Son of sevenless Gene Map to Murine Chromosomes 17 and 12 and to Human Chromosomes 2 and 14, Respectively

Graham C. Webb, Nancy A. Jenkins, David A. Largaespada, Neal G. Copeland, Caroline S. Fernandez, David D.L. Bowtell

Journal:

Year:

1993

File:

PDF, 364 KB

1993

36

Isolation and Preliminary Characterization of the Human and Mouse Homologues of the Bacterial Cell Cycle Gene era

Robert A. Britton, Su-Min Chen, Deeann Wallis, Thearith Koeuth, Bradford S. Powell, Lisa G. Shaffer, David Largaespada, Nancy A. Jenkins, Neal G. Copeland, Donald L. Court, James R. Lupski

Journal:

Year:

2000

Language:

english

File:

PDF, 235 KB

english, 2000

37

Transforming science: cancer gene identification

Lara S Collier, David A Largaespada

Journal:

Current Opinion in Genetics & Development

Year:

2006

Language:

english

File:

PDF, 280 KB

english, 2006

38

Why men are at higher risk for hepatocellular carcinoma?

Vincent W. Keng, David A. Largaespada, Augusto Villanueva

Journal:

Journal of Hepatology

Year:

2012

Language:

english

File:

PDF, 236 KB

english, 2012

39

Target-site Preferences of Sleeping Beauty Transposons

Geyi Liu, Aron M. Geurts, Kojiro Yae, A.R. Srinivasan, Scott C. Fahrenkrug, David A. Largaespada, Junji Takeda, Kyoji Horie, Wilma K. Olson, Perry B. Hackett

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 756 KB

english, 2005

40

Transposon-mediated mutagenesis of somatic cells in the mouse for cancer gene identification

David A. Largaespada

Journal:

Year:

2009

Language:

english

File:

PDF, 279 KB

english, 2009

41

Models of acute myeloid leukemia: Prospects for drug development and testing

Bin Yin, David A. Largaespada

Journal:

Drug Discovery Today: Disease Models

Year:

2006

Language:

english

File:

PDF, 205 KB

english, 2006

42

Generating and manipulating transgenic animals using transposable elements

David A Largaespada

Journal:

Reproductive Biology and Endocrinology

Year:

2003

Language:

english

File:

PDF, 982 KB

english, 2003

43

Interweaving the Strands: β-Catenin, an HIV Co-Receptor, and Schwann Cell Tumors

Largaespada, David, Ratner, Nancy

Journal:

Year:

2013

Language:

english

File:

PDF, 200 KB

english, 2013

44

A Transposon and Transposase System for Human Application

Hackett, Perry B, Largaespada, David A, Cooper, Laurence JN

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 833 KB

english, 2010

45

Transposable elements and the dynamic somatic genome

Lara S Collier, David A Largaespada

Journal:

Year:

2007

Language:

english

File:

PDF, 82 KB

english, 2007

46

Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies

Tschida, Barbara R., Largaespada, David A., Keng, Vincent W.

Journal:

Seminars in Cell & Developmental Biology

Year:

2014

Language:

english

File:

PDF, 1.46 MB

english, 2014

47

Retrotransposons: A new and credible source of inherited and somatically acquired hepatocellular carcinoma mutations

Rahrmann, Eric P., Largaespada, David A.

Journal:

Journal of Hepatology

Year:

2013

Language:

english

File:

PDF, 225 KB

english, 2013

48

Expression of FGFR3 and FGFR4 and clinical risk factors associated with progression-free survival in synovial sarcoma

Charbonneau, Bridget, Vogel, Rachel Isaksson, Manivel, J. Carlos, Rizzardi, Anthony, Schmechel, Stephen C., Ognjanovic, Simona, Subramanian, Subbaya, Largaespada, David, Weigel, Brenda

Journal:

Human Pathology

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

49

Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy

Hackett, Perry B., Largaespada, David A., Switzer, Kirsten C., Cooper, Laurence J.N.

Journal:

Translational Research

Year:

2013

Language:

english

File:

PDF, 673 KB

english, 2013

50

169

Litterman, Adam J., Zellmer, David M., Largaespada, David A.

Journal:

Year:

2013

Language:

english

File:

PDF, 54 KB

english, 2013